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Colors：We have prepared notebooks in various colors for you ，you can use it to make the trivial daily plan, recording your life.
Usage：This notebooks are suitable for journal, business, notes, diary and more, also can be used as class notes for students or learners, useful supplies for schools and offices.You can also treat it as the gift of memories with a lovely soft cover travel notebook.
Size：size of the notebook paper are 23*18cm.The suitable size are convenient for your daily use.
Advantage：Sheets are perforated for easy removal. The various colors give you a colorful life. It is also a great decoration for your desktop.And you could use it to clarify your work types.Each color stands for one subject.
Material: imitation leather
Body paper size :A5
Number of sheets: 200 pages
Colour:Black , Blue , Brown , Gray , Red
Multifunctional inside, can put small objects, bank cards, cards, etc
Metal binder, selected hardware materials, easy to take, and the cover can be reused
Computer records cannot replace the profoundness of writing
Quality service: If you have any questions during the shopping process, please contact us in time, and we will give you a satisfactory answer within 24 hours.
Molecular pathway of estrogen receptor (ER) action. Typically, estrogen binds to the ligand-binding domain of receptors in the nucleus, which causes a conformational change. Estrogen-responsive elements (ERE) mediate genomic effects. RE, response element; TF, transcription factor; GF, growth factor; GF-R, growth factor receptor; CoA, co-activator; CoR, co-repressor; MAPK, mictogen-activated protein kinase; PI3K, phophoinositide 3-kinase; Src, proto-oncogene tyrosine-protein kinase; AP-1, activating protein-1; Sp-1, stimulating protein-1. Adapted from Nie et al.16
Measurement parameters utilized to determine the esophageal motor function. (A) Esophagogastric junction (EGJ). (B) Esophageal body. EGJ-CI, esophagogastric junction-contractile integral; IRP, integrated relaxation pressure; LES, lower esophageal sphincter.
High-resolution manometry test swallows and maneuvers. (A) Supine 5 mL liquid; (B) upright 5 mL liquid; (C) viscous (apple sauce); (D) solid (graham cracker); (E) multiple rapid swallow; and (F) rapid drink challenge. Integrated relaxation pressure (IRP) and distal contractile integral (DCI) were 11 mmHg and 1760 mmHg·cm·sec (A), 8 mmHg and 1950 mmHg·cm·sec (B), 7 mmHg and 1600 mmHg·cm·sec (C), 10 mmHg and 1400 mmHg·cm·sec (D), 4 mmHg and 4600 mmHg·cm·sec (E), and 3 mmHg and 0 mmHg·cm·sec (F), respectively. Figure used with permission from the Esophageal Center at Northwestern.
Our diagnostic algorithm of defecation disorders using a colonic transit study. DD, defecation disorders; DRE, digital rectal examination; NTC, normal transit constipation; STC, slow transit constipation; RS, rectosigmoid colon.
Statistical maps showing voxel-mirrored homotopic connectivity (VMHC) differences between irritable bowel syndrome (IBS) and healthy controls (HCs;